It's the most common treatment for removing cell changes in the cervix. There were fewer pregnancies in women following a cold knife cone or more than one LLETZ treatment-significant surgery, (p=0.004) but no difference in their reported time to conception (p=0.54). LLETZ is also called loop diathermy, loop cone, loop biopsy or loop excision. Some studies suggest that sub-fertile women who attend for IVF are more likely to have abnormal cervical cytology. In the UK, it is known as large loop excision of the transformation zone (LLETZ).. LEEP has many advantages including low cost, high success rate,. Over the last 20 years, cervical screening programs have had huge success in reducing cervical cancer rates. It is also called as loop electrosurgical excision procedure or LEEP. LLETZ has been shown to be associated with a small increased risk of early delivery of babies. In the UK, large loop excision of the transformation zone (LLETZ) is the preferred treatment, with some units offering alternative techniques more frequently than others. There is a small chance of complications with the procedure. Only 57 women reported trying to become pregnant, of whom 11 succeeded, but 144 women did not answer this question on intention to become pregnant. The loop electrosurgical excision procedure (LEEP) is one of the most commonly used approaches to treat high grade cervical dysplasia (CIN II/III, HGSIL) discovered on colposcopic examination. The cases will be identified by using the Mediscan database in the colposcopy clinic to identify those women who have had a LLETZ procedure and those who have had a cone biopsy will be identified by accessing pathology records for cone biopsies for the specified years. Pooled risk ratios (RR) and 95% confidence intervals (CI) were calculated using a random-effects model and inter-study heterogeneity was assessed with I 2.Two review authors (MK, AM) independently assessed the eligibility of retrieved papers and risk of bias. But stopping smoking will improve your partner's general health. Women with abnormal smears are followed up in colposcopy clinics, and where needed, cervical surgery is performed to remove pre-cancerous areas on the cervix. There have been no large studies investigating the effect cervical surgery may have on fertility. There is rarely an impact on fertility and pregnancy after a LEEP. Follow up after the LLETZ procedure is very important to ensure that all abnormal cells have been removed and there are no further cell changes. Surgery to the cervix can include LLETZ (Large loop excision of the transformation zone) treatment or cone biopsy. As with cone biopsy, studies looking at pregnancy after LLETZ show that there is a small rise in risk of birth before 37 weeks and having a low birth weight baby. For general information, Learn About Clinical Studies. In this procedure an electric current is passed through a thin wire loop electrode to excise or cut the abnormal lesion on the cervix. U.S. Department of Health and Human Services, The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. No study has looked at whether this size effect also relates to fertility. These studies have mainly found an association between LLETZ treatment and an increased risk of preterm labour. Adhesions on the cervix may cause pain during your period, fertility problems, and delivery problems. Infertility is estimated to affect approximately one in six to one in ten couples and only about half of these seek medical assistance. It is a simple and safe way of removing a small part of the cervix … [ Time Frame: 12 months ], The number of women who have had repeat surgery and have subfertility. Many studies in the last few years have looked at the impact that this necessary surgery can have on the function of the cervix. The acronym LLETZ refers to large loop excision of the transformation zone, a treatment modality used in patients with cervical dysplasia. Choosing to participate in a study is an important personal decision. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. Box 21, Spring Hill 4004. In one study, in cases of early-stage cervical cancer, after LLETZ resection no impairment of fertility was observed. I had normal smears since but recently had an abnormal smear and biopsy showing CIN2 and another LLETZ treatment required. 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